Epidemiology and Health

Cohort profile

Cohort profile: Epidemiologic Questionnaire (EPI-Q) – a scalable, app-based health survey linked to electronic health record and genotype data: Maxwell Salvatore, Dylan Clark-Boucher, Lars G Fritsche, Jacob Ortlieb, Janet Houghtby, Anisa Driscoll, Bryanne Caldwell-Larkins, Jennifer A Smith, Chad M Brummett, Sachin Kheterpal, Lynda Lisabeth, Bhramar Mukherjee; Epidemiol Health. 2023;e2023074. Published online August 8, 2023; DOI: https://doi.org/10.4178/epih.e2023074 [Accepted]

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Abstract PDF: Abstract
The Epidemiologic Questionnaire (EPI-Q) was established to collect broad, uniform, self-reported health data to supplement electronic health record (EHR) and genotype information from participants in the University of Michigan (UM) Precision Health cohorts. Recruitment of EPI-Q participants, who were already enrolled in 1 of 3 ongoing UM Precision Health cohorts—the Michigan Genomics Initiative, Mental Health Biobank, and Metabolism, Endocrinology, and Diabetes cohorts—began in March 2020. Of 54,043 retrospective invitations, 5,577 individuals enrolled, representing a 10.3% response rate. Of these, 3,502 (63.7%) were female, and the average age was 56.1 years (standard deviation, 15.4 years). The baseline survey comprises 11 modules on topics including personal and family health history, lifestyle, and cancer screening and history. Additionally, 11 optional modules cover topics including financial toxicity, occupational exposure, and life meaning. The questions are based on standardized and validated instruments used in other cohorts, and we share resources to expedite development of similar surveys. Data are collected via the MyDataHelps platform, which enables current and future participants to share non-Michigan Medicine EHR data. Recruitment is ongoing. Cohort data are available to those with institutional review board approval; for details, contact the Data Office for Clinical and Translational Research (DataOffice@umich.edu; (734) 615-2100).; Summary

Cohort Profiles

Integrated database-based Screening Cohort for Asian Nomadic descendants in China (Scan-China): Insights on prospective ethnicity-focused cancer screening: Yuelin Yu, Liying Qiao, Jing Han, Weiwei Wang, Weiwei Kang, Yunjing Zhang, Shu Shang, Ruogu Meng, Lin Zhuo, Siyan Zhan, Yunfeng Xi, Shengfeng Wang; Epidemiol Health. 2023;45:e2023048. Published online April 18, 2023; DOI: https://doi.org/10.4178/epih.e2023048

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Established in 2017, the Screening Cohort for Asian Nomadic descendants in China (Scan-China) has benefited over 180,000 members of a multi-ethnic population, particularly individuals of Mongolian descent compared with the general population (Han ethnicity), in the Inner Mongolia Autonomous Region, China. This cohort study aims to evaluate the effectiveness of cancer screening and serve as a real-world data platform for cancer studies. The 6 most prevalent cancers in China are considered—namely, breast, lung, colorectal, gastric, liver and esophageal cancer. After baseline cancer risk assessments and screening tests, both active and passive follow-up (based on the healthcare insurance database, cancer registry, the front page of hospital medical records, and death certificates) will be conducted to trace participants’ onset and progression of cancers and other prevalent chronic diseases. Scan-China has preliminarily found a disproportionately lower screening participation rate and higher incidence/mortality rates of esophageal and breast cancer among the Mongolian population than among their Han counterparts. Further research will explore the cancer burden, natural history, treatment patterns, and risk factors of the target cancers.; Summary

Key Message
- Scan-China is the first and largest electronic health data (EHD)-integrated cancer screening program for the Mongolian ethnicity in Inner Mongolia. - Scan-China aims to evaluate the effectiveness of screening interventions, particularly on ethnic minorities, portray the natural history, explore risk factors and summarize treatment patterns and updated outcomes of prevalent tumors/other chronic diseases. - Scan-China database comprises baseline cancer risk assessment, screening tests results, active follow-up investigation for participants at high risk and EHD-integrated passive follow-up. Data sources for passive follow-up include healthcare insurance database, cancer registry, front page of hospital medical record and death certificates.

The Asenze Cohort Study in KwaZulu-Natal, South Africa: protocol and cohort profile: Chris Desmond, Gabriella A. Norwitz, Jane D. Kvalsvig, Rachel S. Gruver, Shuaib Kauchali, Kathryn G. Watt, Nonhlanhla P. Myeza, Adele Munsami, Leslie L. Davidson; Epidemiol Health. 2022;44:e2022037. Published online April 5, 2022; DOI: https://doi.org/10.4178/epih.e2022037

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The Asenze cohort is set in South Africa, a middle-income country impacted by one of the highest global rates of people living with HIV/AIDS and high levels of socioeconomic inequality. This longitudinal population-based cohort of children and their primary caregivers assesses household and caregiver functioning, child health, social well-being, and neuro-development from childhood through adolescence. Almost 1,600 children born at the peak of the human immunodeficiency virus epidemic (2003-2005) were followed (with their primary caregivers) in 3 waves, between 2008 and 2021, at average ages of 5, 7, and 16. Wave 3 is currently underway, having assessed over 1,100 of the original wave 1 children. Wave 4 begins in 2022. The study, with a dyadic structure, uses a broad range of measures, validated in South Africa or recommended for global use, that address physical, social and neuro-development in childhood and adolescence, and the social, health, and psychological status of children’s primary caregivers. The Asenze study deepens our understanding of childhood physical, cognitive, and social abilities and/or disabilities, including risk-taking behaviors, and biological, environmental, and social determinants of health. We anticipate the findings will contribute to the development of community-informed interventions to promote well-being in this South African population and elsewhere.; Summary

Key Message
The Asenze Cohort Study, one of a limited number of population-based studies set in low- and middle-income countries, with a high level of retention, provides an understanding of neuro-developmental, psychosocial, home environmental and economic exposures and outcomes of over 1100 adolescents and their primary caregivers in KwaZulu-Natal, South Africa.

Cohort profile: Singapore’s nationally representative Retirement and Health Study with 5 waves over 10 years: Reuben Ng, Yi Wen Tan, Kelvin Bryan Tan; Epidemiol Health. 2022;44:e2022030. Published online February 21, 2022; DOI: https://doi.org/10.4178/epih.e2022030

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Abstract

The Retirement and Health Study (RHS) is Singapore’s largest nationally representative cohort with over 15,000 participants (aged 45-85 years) followed across five timepoints in 10 years (2014-2024). Accounting for sample weights, the sample represents 1.2 million Singaporeans and permanent residents of a total population of 5.5 million. The RHS sought consent to link survey responses to relevant administrative data, enabling the cross-validation of self-reports with national databases. There are 10 sections in the RHS with over 400 questions, 50% of which are on respondents’ physical and mental health, healthcare utilization and insurance; the remaining 50% are about employment history, retirement adequacy, wealth, and household expenditure. The RHS was set up to provide microdata to compliment administrative data for whole-of-government policy making given that Singapore will reach super-aged status by 2026. Sample findings include a need for older adults to balance between immediate financial needs and investments regarding their pension funds. Also, 86% of older adults preferred to transit into partial retirement by reducing workloads. On the health front, existing studies utilising the RHS have revealed latent classes of disabilities, and that intentions to seek employment can mitigate disability developments. Another study reported that physical disability and social isolation was projected to increase, with ethnic disparities in social functioning. Overall, the RHS will be used for evidenced-informed policy agenda setting and evaluation across domains of health, finance, retirement adequacy, social and family development.

Summary

Key Message
The Retirement and Health Study (RHS) is Singapore’s largest nationally representative cohort with over 15,000 participants (aged 45-85 years) followed across five timepoints in 10 years (2014-2024). Sample findings include a need for older adults to balance between immediate financial needs and investments regarding their pension funds. Overall, the RHS will be used for evidenced-informed policy agenda setting and evaluation across domains of health, finance, retirement adequacy, social and family development.

Citations

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Not Too Old for TikTok: How Older Adults Are Reframing Aging
Reuben Ng, Nicole Indran, Barbara J Bowers
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Ageism on Twitter during the COVID‐19 pandemic
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Journal of Social Issues.2022; 78(4): 842. CrossRef
Media attention toward COVID-19 across 18 countries: The influence of cultural values and pandemic severity
Reuben Ng, Yi Wen Tan, Miguel A. Andrade-Navarro
PLOS ONE.2022; 17(12): e0271961. CrossRef

The Dehgolan Prospective Cohort Study (DehPCS) on non-communicable diseases in a Kurdish community in the west of Iran: Farhad Moradpour, Ebrahim Ghaderi, Ghobad Moradi, Mojdeh Zarei, Amjad Mohamadi Bolbanabad, Bakhtiar Piroozi, Azad Shokri; Epidemiol Health. 2021;43:e2021075. Published online October 1, 2021; DOI: https://doi.org/10.4178/epih.e2021075

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Abstract

The Dehgolan Prospective Cohort Study (DehPCS) was conducted to examine and identify risk factors for the most prevalent non-communicable diseases (NCDs). In addition, in order to examine participants’ health status, socioeconomic status, behavioral factors, nutritional status, and environmental exposures, the DehPCS collected, analyzed, and stored blood, urine, nail, and hair samples to conduct genetic studies and identify biomarkers and other biological determinants of NCDs. In total, 3,996 adults aged 35 to 70 from the general population participated in the study from February 2018 to March 2019. Of them, 43.7% were women. The first follow-up wave was conducted with 3,995 participants. Information on a wide range of variables was collected, including on socioeconomic status, lifestyle, nutritional status, habits, physical examination findings, medication use, and medical history. Proxy variables such as body mass index, metabolic equivalent task score, wealth index, and macronutrients and micronutrients were calculated. The most common self-reported diseases in descending order were kidney stones, hypertension, and fatty liver. The prevalence of diabetes and hypertension was 9.3% and 33.4%, respectively. All data, samples, and measurements will be collected again at 5-year intervals. Thus, it will be possible to examine time-dependent changes in the risk factors of NCDs. The DehPCS can be used to study the relationships among genetics, lifestyle, socioeconomic status, and environmental risk factors and the most prevalent NCDs in case-cohort studies using a nested case-control design that will be applied to the cohort infrastructure. Researchers can also submit pre-proposals via the following web address: http://c.ddrc.ac.ir/persianaccess/Account/Login.

Summary

Key Message
• The DehPCS was designed to examine NCDs among the Kurdish population, who are located in a wide area between the northwest of the Zagros Mountains and the eastern Taurus Mountains covering Turkey, Iraq, Iran, and Syria. • In total, 3,996 adults aged 35 to 70 from the general population participated in the study. • All data, samples, and measurements from the registration phase will be collected again at 5-, 10-, and 15-year intervals. • After labeling, aliquots were placed in a freezer at -70°C to enable ongoing studies of the samples in the future.

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Validity of self‐reported hypertension and related factors in the adult population: Preliminary results from the cohort in the west of Iran
Negar Piri, Yousef Moradi, Reza Ghanei Gheshlagh, Mahsa Abdullahi, Eghbal Fattahi, Farhad Moradpour
The Journal of Clinical Hypertension.2023; 25(2): 146. CrossRef
The association between nutrients and occurrence of COVID‐19 outcomes in the population of Western Iran: A cohort study
Dana Vaisi, Farhad Moradpour, Shadieh Mohammadi, Daem Roshani, Yousef Moradi
The Clinical Respiratory Journal.2023; 17(6): 589. CrossRef
Socio-demographic correlates of diabetes self-reporting validity: a study on the adult Kurdish population
Farhad Moradpour, Negar Piri, Hojat Dehghanbanadaki, Ghobad Moradi, Mahdiyeh Fotouk-Kiai, Yousef Moradi
BMC Endocrine Disorders.2022;[Epub] CrossRef
Prevalence of prediabetes, diabetes, diabetes awareness, treatment, and its socioeconomic inequality in west of Iran
Farhad Moradpour, Satar Rezaei, Bakhtiar Piroozi, Ghobad Moradi, Yousef Moradi, Negar Piri, Azad Shokri
Scientific Reports.2022;[Epub] CrossRef

Cohort profile: the Environmental-Pollution-Induced Neurological EFfects (EPINEF) study: a multicenter cohort study of Korean adults: Heeseon Jang, Woojin Kim, Jaelim Cho, Jungwoo Sohn, Juhwan Noh, Gayoung Seo, Seung-Koo Lee, Young Noh, Sung Soo Oh, Sang-Baek Koh, Hee Jin Kim, Sang Won Seo, Ho Hyun Kim, Jung Il Lee, Sun-Young Kim, Changsoo Kim; Epidemiol Health. 2021;43:e2021067. Published online September 16, 2021; DOI: https://doi.org/10.4178/epih.e2021067

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Abstract

The general population is exposed to numerous environmental pollutants, and it remains unclear which pollutants affect the brain, accelerating brain aging and increasing the risk of dementia. The Environmental-Pollution-Induced Neurological Effects study is a multi-city prospective cohort study aiming to comprehensively investigate the effect of different environmental pollutants on brain structures, neuropsychological function, and the development of dementia in adults. The baseline data of 3,775 healthy elderly people were collected from August 2014 to March 2018. The eligibility criteria were age ≥50 years and no self-reported history of dementia, movement disorders, or stroke. The assessment included demographics and anthropometrics, laboratory test results, and individual levels of exposure to air pollution. A neuroimaging sub-cohort was also recruited with 1,022 participants during the same period, and brain magnetic resonance imaging and neuropsychological tests were conducted. The first follow-up environmental pollutant measurements will start in 2022 and the follow-up for the sub-cohort will be conducted every 3-4 years. We have found that subtle structural changes in the brain may be induced by exposure to airborne pollutants such as particulate matter 10 μm or less in diameter (PM₁₀), particulate matter 2.5 μm or less in diameter (PM_2.5) and Mn₁₀, manganese in PM₁₀; Mn_2.5, manganese in PM_2.5. PM₁₀, PM_2.5, and nitrogen dioxide in healthy adults. This study provides a basis for research involving large-scale, long-term neuroimaging assessments in community-based populations.

Summary

Korean summary
EPINEF 코호트는 환경유해인자에 의한 신경계 질환의 위해성을 평가하고, 환경유해인자로 유발되는 신경심리학적 기능 저하 또는 뇌 노화에 대한 근거를 제공하기 위해 2014년부터 50세 이상의 건강한 성인을 대상으로 시작되었습니다. 본 코호트는 뇌 영상학적 표지자와 인지 기능과 관련된 환경유해인자를 광범위하게 조사한 한국 최초의 장기 추적관찰 연구로, 대기 오염 물질 또는 다환방향족탄화수소 노출이 대뇌 영상표지자 및 신경심리학적 기능, 노인의 우울 증상에 대한 악화 요인으로서의 대기오염물질 노출과 결혼 상태의 교호작용 등의 연구결과들을 발표하였습니다. 또한, 추후에도 코호트의 지속적인 추적을 통해 환경유해인자 노출에 따른 신경학적 건강영향을 연구하여, 신경계 질환 관리를 위한 보건 정책 개선에 기여할 수 있을 것으로 기대됩니다.

Key Message
The EPINEF cohort was started in 2014 to assess the risk of neurological diseases caused by environmental harmful factors and to provide evidence for neuropsychological dysfunction or brain aging induced by these factors. This cohort is the first long-term follow-up study in Korea to extensively investigate brain imaging markers and environmental harmful factors related to cognitive function, and several related research results have been published. In addition, the follow-up survey will be continued in the future, and we expect that the results of the study will contribute to improving health policies for the management of neurological diseases.

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Associations of Particulate Matter Exposures With Brain Gray Matter Thickness and White Matter Hyperintensities: Effect Modification by Low-Grade Chronic Inflammation
Jaelim Cho, Heeseon Jang, Young Noh, Seung-Koo Lee, Sang-Baek Koh, Sun-Young Kim, Changsoo Kim
Journal of Korean Medical Science.2023;[Epub] CrossRef
Polycyclic aromatic hydrocarbons and changes in brain cortical thickness and an Alzheimer's disease-specific marker for cortical atrophy in adults: A longitudinal neuroimaging study of the EPINEF cohort
Jaelim Cho, Jungwoo Sohn, Sung Hee Yang, Seung-Koo Lee, Young Noh, Sung Soo Oh, Sang-Baek Koh, Changsoo Kim
Chemosphere.2023; 338: 139596. CrossRef
Surveillance of long-term environmental elements and PM2.5 health risk assessment in Yangtze River Delta, China, from 2016 to 2020
Keqin Wu, Yuanhua Meng, Yan Gong, Xuhui Zhang, Linlin Wu, Xinliang Ding, Xiaofeng Chen
Environmental Science and Pollution Research.2022; 29(54): 81993. CrossRef
Reduced brain subcortical volumes in patients with glaucoma: a pilot neuroimaging study using the region-of-interest-based approach
Yae Won Ha, Heeseon Jang, Sang-Baek Koh, Young Noh, Seung-Koo Lee, Sang Won Seo, Jaelim Cho, Changsoo Kim
BMC Neurology.2022;[Epub] CrossRef

Cohort profile: the Ewha Birth and Growth Study: Hye Ah Lee, Bohyun Park, Jungwon Min, Eun Jeong Choi, Ui Jeong Kim, Hyun Jin Park, Eun Ae Park, Su Jin Cho, Hae Soon Kim, Hwayoung Lee, Young Ju Kim, Young Sun Hong, Eui-Jung Kim, Eun Hee Ha, Hyesook Park; Epidemiol Health. 2021;43:e2021016. Published online February 22, 2021; DOI: https://doi.org/10.4178/epih.e2021016

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Abstract

With the introduction of life-course epidemiology, researchers realized the importance of identifying risk factors in early life to prevent chronic diseases. This led to the establishment of the Ewha Birth and Growth Study in 2001; the study is a prospective birth cohort designed to provide evidence of early life risk factors for a child’s growth and health. Participants were recruited from those who visited Ewha Womans University Mokdong Hospital (a tertiary hospital in southwest Seoul, Korea) for prenatal care at 24-28 weeks of gestation. In total, 891 mothers enrolled in this study between 2001 and 2006 and their offspring (n=940) were followed-up. Regular check-up examinations of offspring were conducted at 3 years, 5 years, and 7 years of age and every year thereafter. To consider age-related health issues, extensive data were collected using questionnaires and measurements. In 2021, the study subjects will reach 19 years of age, and we are planning a check-up examination for early adulthood. About 20 years have passed since the cohort data were collected, and we have published results on childhood health outcomes associated with prenatal and birth characteristics, genetic and epigenetic characteristics related to childhood metabolism, the effects of exposure to endocrine disruptors, and dietary patterns in childhood. Recently, we started reporting on topics related to adolescent health. The findings will facilitate identification of early life risk factors for chronic diseases and the development of interventions for diseases later in life.

Summary

Korean summary
이화영아성장코호트는 만성질환 예방을 위한 생애초기 위험인자에 대한 근거를 제공하기 위해 2001년에 시작되었습니다. 이화영아성장코호트는 국내에서 선도적인 장기 추적관찰 연구로, 소아기 건강과 관련된 산전 및 출생 시 특징, 소아기 대사와 관련된 유전적 혹은 후성학적 특성, 내분비 장애물질 노출에 따른 영향, 소아기의 식이패턴과 같은 다양한 연구결과들을 발표하였습니다. 추후 청년기의 자료 수집을 계획하고 있으며, 우리의 연구결과는 만성질환 예방을 위한 중재 개발에 기여할 것으로 기대됩니다.

Key Message
To provide evidence of early life risk factors for the prevention of chronic diseases, the Ewha Birth and Growth Study was started in 2001. The Ewha Birth and Growth cohort is a leading long-term follow-up study in Korea, and we have published results on childhood health outcomes associated with prenatal and birth characteristics, genetic and epigenetic characteristics related to childhood metabolism, the effects of exposure to endocrine disruptors, and dietary patterns in childhood. We are planning to collect data for early adulthood, and our findings will contribute to the development of interventions to prevent chronic diseases.

Citations

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Prospective association between phthalate exposure in childhood and liver function in adolescence: the Ewha Birth and Growth Cohort Study
Seonhwa Lee, Hye Ah Lee, Bohyun Park, Hyejin Han, Young Sun Hong, Eun Hee Ha, Hyesook Park
Environmental Health.2023;[Epub] CrossRef
BMI trajectory and inflammatory effects on metabolic syndrome in adolescents
Ui-Jeong Kim, Eun Jeong Choi, Hyunjin Park, Hye Ah Lee, Bohyun Park, Jungwon Min, Eun Ae Park, Su Jin Cho, Hae Soon Kim, Hwayoung Lee, Young Ju Kim, Young Sun Hong, Eun Hee Ha, Seungyoun Jung, Hyesook Park
Pediatric Research.2023; 94(1): 153. CrossRef
The Effect of Childhood Obesity or Sarcopenic Obesity on Metabolic Syndrome Risk in Adolescence: The Ewha Birth and Growth Study
Hyunjin Park, Seunghee Jun, Hye-Ah Lee, Hae Soon Kim, Young Sun Hong, Hyesook Park
Metabolites.2023; 13(1): 133. CrossRef
Synergistic effect of serum uric acid and body mass index trajectories during middle to late childhood on elevation of liver enzymes in early adolescence: Findings from the Ewha Birth and Growth Study
Sung Hee Lee, Eun Jeong Choi, Ui Jeong Kim, Hyunjin Park, Bomi Park, Hye Ah Lee, Hyesook Park, Linglin Xie
PLOS ONE.2023; 18(4): e0282830. CrossRef
The association between urinary cotinine level and metabolic syndrome profiles among adolescents: findings from the Ewha Birth and growth study
Hyunjin Park, Ui-Jeong Kim, Eun Jeong Choi, Seunghee Jun, Bomi Park, Hye Ah Lee, Hae Soon Kim, Hyesook Park
BMC Public Health.2023;[Epub] CrossRef
The Mediating Effect of Inflammation between the Dietary and Health-Related Behaviors and Metabolic Syndrome in Adolescence
Ui-Jeong Kim, Eun-Jeong Choi, Hyunjin Park, Hye-Ah Lee, Bomi Park, Haesoon Kim, Youngsun Hong, Seungyoun Jung, Hyesook Park
Nutrients.2022; 14(11): 2339. CrossRef
Precision medicine via the integration of phenotype-genotype information in neonatal genome project
Xinran Dong, Tiantian Xiao, Bin Chen, Yulan Lu, Wenhao Zhou
Fundamental Research.2022; 2(6): 873. CrossRef
Association of participation in the Northern Finland Birth Cohort 1986 with mental disorders and suicidal behaviour
Martta Kerkelä, Mika Gissler, Juha Veijola
Epidemiology and Health.2022; 44: e2022005. CrossRef
Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence
Eun Jeong Choi, Hye Ah Lee, Bomi Park, Bohyun Park, Hae Soon Kim, Young Sun Hong, Hyesook Park
Scientific Reports.2021;[Epub] CrossRef

Cohort profile: congenital Zika virus infection and child neurodevelopmental outcomes in the ZEN cohort study in Colombia: Maritza Gonzalez, Van T. Tong, Helena Rodriguez, Diana Valencia, Jacqueline Acosta, Margaret A. Honein, Martha L. Ospina; Epidemiol Health. 2020;42:e2020060. Published online August 31, 2020; DOI: https://doi.org/10.4178/epih.e2020060

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Abstract

Zika en Embarazadas y Niños (ZEN) is a prospective cohort study designed to identify risk factors and modifiers for Zika virus (ZIKV) infection in pregnant women, partners, and infants, as well as to assess the risk for adverse maternal, fetal, infant, and childhood outcomes of ZIKV and other congenital infections. ZIKV infection during pregnancy may be associated with longterm sequelae. In the ZEN cohort, 1,519 pregnant women and 287 partners were enrolled from 3 departments within Colombia between February 2017 and January 2018, as well as 1,108 infants born to the pregnant women who were followed to 6 months. The data include baseline questionnaires at enrollment; repeated symptoms and study follow-up questionnaires; the results of lab tests to detect ZIKV and other congenital infections; medical record abstractions; infant physical, eye, and hearing exams; and developmental screening tests. Follow-up of 850 mother-child dyads occurred at 9 months, 12 months, and 18 months with developmental screenings, physical exams, and parent questionnaires. The data will be pooled with those from other prospective cohort studies for an individual participant data meta-analysis of ZIKV infection during pregnancy to characterize pregnancy outcomes and sequelae in children.

Summary

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Zika virus knowledge, attitudes and prevention behaviors among pregnant women in the ZEN cohort study, Colombia, 2017–2018
Veronica K Burkel, Suzanne M Newton, Jacqueline Acosta, Diana Valencia, Monica Benavides, Van T Tong, Marcela Daza, Christina Sancken, Maritza Gonzalez, Kara Polen, Helena Rodriguez, Milena Borbón, Carol Y Rao, Suzanne M Gilboa, Margaret A Honein, Marta L
Transactions of The Royal Society of Tropical Medicine and Hygiene.2023; 117(7): 496. CrossRef
Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia
Angelica Rico, Sheila C. Dollard, Diana Valencia, Sheryll Corchuelo, Van T. Tong, Katherine Laiton‐Donato, Minal M. Amin, Monica Benavides, Phili Wong, Suzanne Newton, Marcela Daza, Jordan Cates, Maritza Gonzalez, Laura D. Zambrano, Marcela M. Mercado, El
Journal of Medical Virology.2021; 93(11): 6393. CrossRef
Causes of Phenotypic Variability and Disabilities after Prenatal Viral Infections
Youssef A. Kousa, Reafa A. Hossain
Tropical Medicine and Infectious Disease.2021; 6(2): 95. CrossRef

Cohort profile: the Kisalaya cohort of mother-infant dyads in rural south India (2008-2012): Smitha Chandrashekarappa, Krupa Modi, Karl Krupp, Kavitha Ravi, Anisa Khan, Vijaya Srinivas, Poornima Jaykrishna, Anjali Arun, Murali Krishna, Purnima Madhivanan; Epidemiol Health. 2020;42:e2020010. Published online March 11, 2020; DOI: https://doi.org/10.4178/epih.e2020010

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Abstract PDF: Abstract
The Kisalaya cohort was established in 2008, providing integrated antenatal care (ANC) and human immunodeficiency virus (HIV) testing in order to reduce adverse birth outcomes and pediatric HIV infections. The program used a mobile clinic model to deliver health education, ANC, and HIV/sexually transmitted infection testing and management to pregnant women in rural communities in southern India. This cohort includes pregnant women residing in 144 villages of the Mysuru taluk (a rural region) who received ANC through the mobile clinic and delivered their infants between 2008 and 2011. Of the 1,940 women registered for ANC at primary healthcare centers during this time period, 1,675 (75.6%) were enrolled in the Kisalaya cohort. Once women enrolled in the Kisalaya cohort gave birth, the cohort expanded to include the mother-infant dyads with a retention rate of 100% at follow-up visits at 15 days and at 6 months post-delivery. The baseline data collected during the Kisalaya study included both questionnaire-based data and laboratory-based investigations. Presently, a study entitled “Early life influences on adolescent mental health: a life course study of the Kisalaya birth cohort in south India” is in the process of data collection (2019-2020).; Summary

Health Effects of Underground Workspaces cohort: study design and baseline characteristics

Gerard Dunleavy, Thirunavukkarasu Sathish, Nuraini Nazeha, Michael Soljak, Nanthini Visvalingam, Ram Bajpai, Hui Shan Yap, Adam C. Roberts, Thuan Quoc Thach, André Comiran Tonon, Chee Kiong Soh, Georgios Christopoulos, Kei Long Cheung, Hein de Vries, Josip Car

Epidemiol Health. 2019;41:e2019025.   Published online August 16, 2019

DOI: https://doi.org/10.4178/epih.e2019025

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Abstract
The development of underground workspaces is a strategic effort towards healthy urban growth in cities with ever-increasing land scarcity. Despite the growth in underground workspaces, there is limited information regarding the impact of this environment on workers’ health. The Health Effects of Underground Workspaces (HEUW) study is a cohort study that was set up to examine the health effects of working in underground workspaces. In this paper, we describe the rationale for the study, study design, data collection, and baseline characteristics of participants. The HEUW study recruited 464 participants at baseline, of whom 424 (91.4%) were followed-up at 3 months and 334 (72.0%) at 12 months from baseline. We used standardized and validated questionnaires to collect information on socio-demographic and lifestyle characteristics, medical history, family history of chronic diseases, sleep quality, health-related quality of life, chronotype, psychological distress, occupational factors, and comfort levels with indoor environmental quality parameters. Clinical and anthropometric parameters including blood pressure, spirometry, height, weight, and waist and hip circumference were also measured. Biochemical tests of participants’ blood and urine samples were conducted to measure levels of glucose, lipids, and melatonin. We also conducted objective measurements of individuals’ workplace environment, assessing air quality, light intensity, temperature, thermal comfort, and bacterial and fungal counts. The findings this study will help to identify modifiable lifestyle and environmental parameters that are negatively affecting workers’ health. The findings may be used to guide the development of more health-promoting workspaces that attempt to negate any potential deleterious health effects from working in underground workspaces.

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Activity Tracker–Based Metrics as Digital Markers of Cardiometabolic Health: Cross-Sectional Study
Yuri Rykov, Thuan-Quoc Thach, Gerard Dunleavy, Adam Charles Roberts, George Christopoulos, Chee Kiong Soh, Josip Car
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Prevalence of psychological distress and its association with perceived indoor environmental quality and workplace factors in under and aboveground workplaces
Gerard Dunleavy, Ram Bajpai, André Comiran Tonon, Kei Long Cheung, Thuan-Quoc Thach, Yuri Rykov, Chee-Kiong Soh, Hein de Vries, Josip Car, Georgios Christopoulos
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Vinita Venugopal, Adam Charles Roberts, Kian-Woon Kwok, George I. Christopoulos, Chee-Kiong Soh
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Thuan‐Quoc Thach, Dhiya Mahirah, Charlotte Sauter, Adam Charles Roberts, Gerard Dunleavy, Nuraini Nazeha, Yuri Rykov, Yichi Zhang, George I. Christopoulos, Chee‐Kiong Soh, Josip Car
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White- and Blue- collar workers responses’ towards underground workspaces
Ying Su, Adam C. Roberts, Hui Shan Yap, Josip Car, Kian Woon Kwok, Chee-Kiong Soh, George I. Christopoulos
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Prevalence of sick building syndrome and its association with perceived indoor environmental quality in an Asian multi-ethnic working population
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Building and Environment.2019; 166: 106420.     CrossRef
A Multifactorial Approach to Sleep and Its Association with Health-Related Quality of Life in a Multiethnic Asian Working Population: A Cross-Sectional Analysis
Gerard Dunleavy, André Comiran Tonon, Ai Ping Chua, Yichi Zhang, Kei Long Cheung, Thuan-Quoc Thach, Yuri Rykov, Chee-Kiong Soh, Georgios Christopoulos, Hein de Vries, Josip Car
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The Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA), India

Padukudru Anand Mahesh, Komarla Sundararaja Lokesh, Purnima Madhivanan, Sindaghatta Krishnarao Chaya, Biligere Siddaiah Jayaraj, Koustav Ganguly, Murali Krishna

Epidemiol Health. 2018;40:e2018027.   Published online June 23, 2018

DOI: https://doi.org/10.4178/epih.e2018027

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Abstract
Between 2006 and 2010, in 16 randomly selected villages in rural areas of Mysore district, in south India, 8,457 subjects aged 30 and above were screened for symptoms of chronic respiratory disease. Of the 8,457 subjects, 1,692 were randomly invited for further evaluation of lung function and chronic obstructive pulmonary disease (COPD) by spirometry, and 1,085 of these subjects underwent lung function assessments for prevalent COPD and its risk factors. These 1,085 subjects, who were then aged between 35 and 80 years, constituted the Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA) cohort. Among other findings, threshold of biomass fuel smoke exposure suitable for use as a dichotomous risk factor for the diagnosis of chronic bronchitis was established, with a minimum biomass smoke exposure index of 60 found to be significantly associated with an elevated risk of developing chronic bronchitis. Five years later (between 2014 and 2016), 869 of the 1,085 participants were followed up with repeat lung function assessments for incident COPD and all-cause mortality. A subset of these participants (n=200) underwent blood tests for vitamin D levels, antioxidant activity, an assessment for anxiety and depression, and another subset (n=98) underwent a bioplex assay for 40 serum cytokines.

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Associations of Vitamin D, chronic obstructive pulmonary disease and acute exacerbations of COPD with anxiety and depression: a nested case control study
Komarla Sundararaja Lokesh, Ananya Ananth Rao, Sindaghatta Krishnarao Chaya, Biligere Siddaiah Jayaraj, Attahalli Shivanarayanprasad Praveena, Murali Krishna, Purnima Madhivanan, Mahesh Padukudru Anand
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Pakistan BioMedical Journal.2022; : 107.     CrossRef
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Laiba Rafiq, Syeda Hamayal Zahra Naqvi, Laila Shahzad, Syed Mustafa Ali
Reviews on Environmental Health.2022;[Epub]     CrossRef
Vitamin D deficiency is associated with chronic obstructive pulmonary disease and exacerbation of COPD
Komarla Sundararaja Lokesh, Sindaghatta Krishnarao Chaya, Biligere Siddaiah Jayaraj, Attahalli Shivanarayanprasad Praveena, Murali Krishna, Purnima Madhivanan, Padukudru Anand Mahesh
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Inflammatory Biomarkers Interleukin 1 Beta (IL-1β) and Tumour Necrosis Factor Alpha (TNF-α) Are Differentially Elevated in Tobacco Smoke Associated COPD and Biomass Smoke Associated COPD
Bellipady Shyam Prasad Shetty, Sindaghatta Krishnarao Chaya, Sravan Kumar V, Maheswarappa Mahendra, Biligere Siddaiah Jayaraj, Komarla Sundararaja Lokesh, Koustav Ganguly, Padukudru Anand Mahesh
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Ashwani Verma, Nachiket Gudi, Uday N Yadav, Manas Pratim Roy, Amreen Mahmood, Ravishankar Nagaraja, Pradeepa Nayak
Journal of Global Health.2021;[Epub]     CrossRef
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Surinder K. Jindal, Ashutosh N. Aggarwal, Aditya Jindal
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Clinical, Epidemiological and Experimental Approaches to Assess Adverse Health Outcomes of Indoor Biomass Smoke Exposure: Conclusions from An Indo-Swedish Workshop in Mysuru, January 2020
Mahesh Padukudru Anand, Kjell Larsson, Gunnar Johanson, Harish C. Phuleria, P. Veeranna Ravindra, Lena Ernstgård, Ulaganathan Mabalirajan, Murali Krishna, Lena Palmberg, Krystal J. Godri Pollitt, Swapna Upadhyay, Koustav Ganguly
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Sangeetha Vishweswaraiah, Tania Ahalya Thimraj, Leema George, Chaya Sindaghatta Krishnarao, Komarla Sundararaja Lokesh, Jayaraj Biligere Siddaiah, Kjell Larsson, Swapna Upadhyay, Lena Palmberg, Mahesh Padukudru Anand, Koustav Ganguly
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Korea HIV/AIDS Cohort Study: study design and baseline characteristics

Bo Youl Choi, Jun Yong Choi, Sang Hoon Han, Sang Il Kim, Mee-Kyung Kee, Min Ja Kim, Shin-Woo Kim, Sung Soon Kim, Yu-Mi Kim, Nam Su Ku, Jin-Soo Lee, Joo-Shil Lee, Yunsu Choi, Kyong Sil Park, Joon Young Song, Jun Hee Woo, Moon Won Kang, June Kim

Epidemiol Health. 2018;40:e2018023.   Published online June 6, 2018

DOI: https://doi.org/10.4178/epih.e2018023

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11 Citations

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Abstract
The number of persons infected by HIV/AIDS has consistently increased in Korea since the first case of HIV/AIDS infection in 1985 and reached 15,208 by 2016. About 1,100 new patients with HIV/ AIDS infections have emerged every year since 2013. In Korea, the Korea HIV/AIDS Cohort Study was established for the evidenced-based prevention, treatment, and effective management of patients infected with human immunodeficiency virus (HIV) in December 2006. This study monitored 1,438 patients, who accounted for about 10% of all patients with HIV/AIDS in Korea, for 10 years with the following aims: (1) to develop an administrative system for the establishment of a HIV/AIDS cohort-based study; (2) to standardize methodologies and the case report forms; and (3) to standardize multi-cohort data and develop a data cleaning method. This study aims to monitor at least 1,000 patients (excluding those for whom investigation had been completed) per year (estimated number of patients who can be monitored by January 2018: 939). By December 2016, the sex distribution was 93.3% for men, and 6.7% for women (gender ratio, 13.9:1.0), and 98.9% of all participants were Korean. More than 50.0% of the participants were confirmed as HIV positive after 2006. This study reports competitive, long-term research that aimed to develop policies for the prevention of chronic infectious diseases for patients with HIV. The data collected over the last decade will be used to develop indices for HIV treatment and health promotion.

Summary

Korean summary
세계적으로 HIV 감염인은 감소하고 있으나, 한국의 HIV 감염은 증가하여 2013년 이후 매년 1,000명이 넘는 신규 감염인이 보고되고 있다. HIV/AIDS 코호트 연구진은 2006년부터 HIV 감염인과 AIDS 환자를 대상으로 6개월 간격의 반복 조사를 시행하여 역학과 임상 자료를 수집하여 데이터베이스를 구축하고, 생물검체를 채취하여 인체자원은행에 보관하여, HIV/AIDS의 발생 기전을 구명하고, 자연사를 파악하며, 예방과 진단, 치료, 관리 방법을 개발하기 위한 기초와 임상, 역학 연구에 활용하고 있다.

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Rate of and Risk Factors for Loss to Follow Up in HIV-Infected Patients in Korea: The Korea HIV/AIDS Cohort Study
Hye Seong, Yunsu Choi, Minjeong Kim, Jung Ho Kim, Joon Young Song, Shin-Woo Kim, Sang Il Kim, Youn Jeong Kim, Dae Won Park, Boyoung Park, Bo Youl Choi, Jun-Yong Choi
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Yunsu Choi, Bo Youl Choi, Sang Il Kim, Jungsoon Choi, Jieun Kim, Bo Young Park, Soo Min Kim, Shin-Woo Kim, Jun Yong Choi, Joon Young Song, Youn Jeong Kim, Hyo Youl Kim, Jin-Soo Lee, Jung Ho Kim, Yoon Hee Jun, Myungsun Lee, Jaehyun Seong
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Kyungmin Kim, Seoyoung Jang, Hyo-Deog Rim, Shin-Woo Kim, Hyun-ha Chang, Jungmin Woo
Psychiatry Investigation.2023; 20(5): 418.     CrossRef
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Kyung Sun Oh, Gi Hyeon Seo, Hee Kyoung Choi, Euna Han
Scientific Reports.2022;[Epub]     CrossRef
Predictors Associated With HIV Status Non-Disclosure in Korea
Kyungmin Kim, Jungmin Woo
Journal of Korean Medical Science.2022;[Epub]     CrossRef
Comparison of Three Cardiovascular Risk Scores among HIV-Infected Patients in Korea: The Korea HIV/AIDS Cohort Study
Ji Yun Bae, Soo Min Kim, Yunsu Choi, Jun Yong Choi, Sang Il Kim, Shin-Woo Kim, Bo Young Park, Bo Youl Choi, Hee Jung Choi
Infection & Chemotherapy.2022; 54(3): 409.     CrossRef
The Incidence and Risk Factors of Renal Insufficiency among Korean HIV infected Patients: The Korea HIV/AIDS Cohort Study
Jun Hyoung Kim, Heeseon Jang, Jung Ho Kim, Joon Young Song, Shin-Woo Kim, Sang Il Kim, Bo Youl Choi, Jun Yong Choi
Infection & Chemotherapy.2022; 54(3): 534.     CrossRef
Estimation of the Number of HIV Infections and Time to Diagnosis in the Korea
Eunyoung Lee, Jungmee Kim, Jin Yong Lee, Ji Hwan Bang
Journal of Korean Medical Science.2020;[Epub]     CrossRef
Human Immunodeficiency Virus-Associated Gastrointestinal Kaposi's Sarcoma: A Case Report
Hee Joong Lim, So Hyun Park, Seung Joon Choi, Suyoung Park, Hee Young Lee, Jun Won Chung, Dong Hae Chung
Journal of the Korean Society of Radiology.2020; 81(5): 1260.     CrossRef
Epidemiological characteristics of HIV infected Korean: Korea HIV/AIDS Cohort Study
Yunsu Choi, Bo Youl Choi, Soo Min Kim, Sang Il Kim, June Kim, Jun Young Choi, Shin-Woo Kim, Joon Young Song, Youn Jeong Kim, Dae Won Park, Hyo Youl Kim, Hee-Jung Choi, Mee-Kyung Kee, Young Hyun Shin, Myeongsu Yoo
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Comparison of Characteristics and Survival between Prospective and Retrospective Korea Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Cohort Studies
Jun Hyoung Kim, Yunsu Choi, Joon Young Song, Shin-Woo Kim, Sang Il Kim, Mee-Kyung Kee, Bo Youl Choi, Jun Yong Choi
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Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) cohort: study protocol and results of the first 3 years of enrollment

Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Hyeon Chang Kim

Epidemiol Health. 2017;39:e2017016.   Published online April 1, 2017

DOI: https://doi.org/10.4178/epih.e2017016

15,550 View

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36 Citations

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Abstract
Although the etiologies of cardiovascular disease (CVD) are widely understood, the goal of finding a globally effective solution for preventing CVD is unrealistic. Therefore, we aimed to conduct a community-based prospective study on the prevention and management of CVD in Korean adults. This study was designed to recruit 8,000 healthy adults over the course of 5 years. The baseline assessment includes a wide range of established CVD risk factors, including demographic characteristics, medical history, health behaviors, psychological conditions, body size and composition, blood pressure, the augmentation index, carotid ultrasonography, an electrocardiogram, and biochemical indicators, as well as some novel factors, such as social network characteristics, exposure to environmental pollutants, inflammatory markers, hemostatic markers, and immunosenescence markers. Annual telephone interviews and follow-up health examinations at 5-year intervals after the baseline assessment are planned to collect information on changes in health status and its determinants. Additionally, indirect follow-up using secondary data sources will be conducted to obtain information on health services utilization and death. So far, more than 6,000 adults have been enrolled during the first three and a half years, and almost all participants have been tracked by annual telephone follow-up surveys. The data have been uploaded to iCReaT, the clinical research information management system of the Korea National Institute of Health.

Summary

Korean summary
심뇌혈관 및 대사질환 원인연구센터(Cardiovascular and Metabolic Diseases Etiology Research Center)에서는 심뇌혈관질환 및 대사질환의 새로운 발병 원인을 찾고 효율적인 예방 전략을 개발하고자 코호트(CMERC cohort와 CMERC-HI cohort)를 구축하였다. 지역사회에 거주하는 만 30-64세 건강한 성인을 대상으로 하는 CMERC cohort는 2013년부터 2018년 까지 총 5년 동안 8000명 등록을 목표로 기반조사를 진행 중이며(2016년 12월 현재 6000여명 등록), 이미 알려진 다양한 위험요인 이외에 사회연결망 정보와 면역노화 관련 바이오마커 등 새로운 위험 요인에 관한 광범위한 정보가 수집되고 있다. CMERC cohort는 심뇌혈관 및 대사질환 예방연구의 기초자료로 활용되어 과학적 데이터에 근거한 예방 전략 수립에 기여하게 될 것이다.

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Jong Hyun Jhee, Donghwan Oh, Jiwon Seo, Chan Joo Lee, Min-Yu Chung, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Sungha Park, Tae-Hyun Yoo
American Journal of Kidney Diseases.2023; 81(4): 384.     CrossRef
Ideal cardiovascular health metrics and the risk of nonalcoholic fatty liver disease in Korean adults
Sun Young Shim, Sun Jae Jung, Seung Up Kim, Hyeon Chang Kim
Clinical Hypertension.2023;[Epub]     CrossRef
Cortical and Trabecular Bone Deficit in Middle‐Aged Men Living with HIV
Namki Hong, Jung Ho Kim, Graham Treece, Hyeon Chang Kim, Jun Yong Choi, Yumie Rhee
Journal of Bone and Mineral Research.2023;[Epub]     CrossRef
Nocturnal systolic blood pressure dipping and progression of chronic kidney disease
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Hypertension Research.2023;[Epub]     CrossRef
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Diabetes & Metabolism Journal.2023; 47(4): 547.     CrossRef
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Journal of Clinical Medicine.2022; 11(9): 2440.     CrossRef
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Clinical & Translational Immunology.2022;[Epub]     CrossRef
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Y. J. Jeon, S. J. Jung, H. C. Kim
European Journal of Neurology.2021; 28(1): 48.     CrossRef
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Naharin Sultana Anni, Sun Jae Jung, Jee-Seon Shim, Yong Woo Jeon, Ga Bin Lee, Hyeon Chang Kim
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Sun Young Shim, Ga Bin Lee, Jee-Seon Shim, Sun Jae Jung, Hyeon Chang Kim
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International Journal of Environmental Research and Public Health.2020; 17(8): 2946.     CrossRef
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Ji Eun Heo, Jee-Seon Shim, Hokyou Lee, Hyeon Chang Kim
Diabetes & Metabolism Journal.2020; 44(3): 446.     CrossRef
Depressive symptoms, its sub-factors, and augmentation index: the modifying effects according to inflammatory markers
Ye Jin Jeon, So Mi Jemma Cho, Yu Jin Lee, Hyeon Chang Kim, Sun Jae Jung
Journal of Affective Disorders.2020; 272: 380.     CrossRef
Ambulatory blood pressure variability and risk of cardiovascular events, all-cause mortality, and progression of kidney disease
Jong Hyun Jhee, Jiwon Seo, Chan Joo Lee, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Sungha Park, Tae-Hyun Yoo
Journal of Hypertension.2020; 38(9): 1712.     CrossRef
Comparison of Computed Tomography-based Abdominal Adiposity Indexes as Predictors of Non-alcoholic Fatty Liver Disease Among Middle-aged Korean Men and Women
Jongmin Baek, Sun Jae Jung, Jee-Seon Shim, Yong Woo Jeon, Eunsun Seo, Hyeon Chang Kim
Journal of Preventive Medicine and Public Health.2020; 53(4): 256.     CrossRef
Effect of Smartphone-Based Lifestyle Coaching App on Community-Dwelling Population With Moderate Metabolic Abnormalities: Randomized Controlled Trial
So Mi Jemma Cho, Jung Hyun Lee, Jee-Seon Shim, Hyungseon Yeom, Su Jin Lee, Yong Woo Jeon, Hyeon Chang Kim
Journal of Medical Internet Research.2020; 22(10): e17435.     CrossRef
The Association of Adiponectin and Visceral Fat with Insulin Resistance and β-Cell Dysfunction
Hyun Uk Moon, Kyoung Hwa Ha, Seung Jin Han, Hae Jin Kim, Dae Jung Kim
Journal of Korean Medical Science.2019;[Epub]     CrossRef
Presence of Metabolic Syndrome Components Is Associated with Tooth Loss in Middle-Aged Adults
Min-Jeong Cho, Youn-Hee Choi, Hyeon Chang Kim, Jee-Seon Shim, Atsuo Amano, Ji-Young Kim, Keun-Bae Song
Yonsei Medical Journal.2019; 60(6): 554.     CrossRef
Cohort Profile: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort in Korea
Jee-Seon Shim, Bo Mi Song, Jung Hyun Lee, Seung Won Lee, Ji Hye Park, Dong Phil Choi, Myung Ha Lee, Kyoung Hwa Ha, Dae Jung Kim, Sungha Park, Won-Woo Lee, Yoosik Youm, Eui-Cheol Shin, Hyeon Chang Kim
Yonsei Medical Journal.2019; 60(8): 804.     CrossRef
Can persistent organic pollutants distinguish between two opposite metabolic phenotypes in lean Koreans?
K.H. Ha, S.A. Kim, Y.M. Lee, D.J. Kim, D.H. Lee
Diabetes & Metabolism.2018; 44(2): 168.     CrossRef
Association between appendicular skeletal muscle mass and depressive symptoms: Review of the cardiovascular and metabolic diseases etiology research center cohort
Ji Eun Heo, Jee-Seon Shim, Bo Mi Song, Hye Yoon Bae, Ho Jae Lee, Eun Lee, Hyeon Chang Kim
Journal of Affective Disorders.2018; 238: 8.     CrossRef
Association of Insulin Resistance with Lower Bone Volume and Strength Index of the Proximal Femur in Nondiabetic Postmenopausal Women
Jaewon Yang, Namki Hong, Jee-Seon Shim, Yumie Rhee, Hyeon Chang Kim
Journal of Bone Metabolism.2018; 25(2): 123.     CrossRef
Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adults
Ji Eun Heo, Hyeon Chang Kim, Jee-Seon Shim, Bo Mi Song, Hye Yoon Bae, Ho Jae Lee, Il Suh
Epidemiology and Health.2018; 40: e2018049.     CrossRef
Comparison of self-reported and accelerometer-assessed measurements of physical activity according to socio-demographic characteristics in Korean adults
Seung Won Lee, Jee-Seon Shim, Bo Mi Song, Ho Jae Lee, Hye Yoon Bae, Ji Hye Park, Hye Rin Choi, Jae Won Yang, Ji Eun Heo, So Mi Jemma Cho, Ga Bin Lee, Diana Huanan Hidalgo, Tae-Hoon Kim, Kyung Soo Chung, Hyeon Chang Kim
Epidemiology and Health.2018; 40: e2018060.     CrossRef
Are Serum Vitamin D Levels Associated With Dry Eye Disease? Results From the Study Group for Environmental Eye Disease
Da-Hye Jeon, Hyungseon Yeom, Jaewon Yang, Jong Suk Song, Hyung Keun Lee, Hyeon Chang Kim
Journal of Preventive Medicine and Public Health.2017; 50(6): 369.     CrossRef

Cohort profile

Cancer screenee cohort study of the National Cancer Center in South Korea

Jeongseon Kim

Epidemiol Health. 2014;36:e2014013.   Published online August 6, 2014

DOI: https://doi.org/10.4178/epih/e2014013

19,002 View

206 Download

27 Citations

Abstract Summary PDF

Abstract
The Cancer Screenee Cohort Study was first established in 2002 by the National Cancer Center in South Korea to investigate all possible risk factors related to cancers and to expand biological specimen banking for the development of effective methodologies for cancer detection, diagnosis, and prevention. As of July in 2014, total 41,105 participants were enrolled in this cohort. Data were collected via questionnaire, clinical examination, cancer screening, and biological specimen testing including blood, urine, and exfoliated cervical cells. The highest incidence was found to be thyroid cancer, according to a nested case-control study that was linked to the National Cancer Registry information as of December 31, 2011. Case-control, cross-sectional, and cohort studies have been published using these data since 2009. Diet and nutrition was the most published topic, followed by genetics, hepatitis B virus and liver cancer screening, methodologies, physical activity, obesity, metabolic syndrome, smoking and alcohol consumption, and blood type. Evidence from the Cancer Screenee Cohort Study is highly anticipated to reduce the burden of cancer in the Korean population and aid in the detection, diagnosis, and prevention of cancer.

Summary

Korean summary
국립암센터에서는 암을 포함한 만성질환의 포괄적인 위험요인 정보와 생물학적 시료은행을 포함하는 연구기반을 확충하기 위해 2002년 8월부터 지금까지 총 41,104건의 코호트가 구축되고 있다 (2014년 7월 31일 현재). 국립암센터 검진자 코호트 자료를 통해 암발생의 위험요인과 암의 자연사 원인을 규명하고, 역학연구 자원을 활용한 본격적인 암 분자역학 연구를 지원할 수 있을 것으로 기대한다. 뿐만 아니라, 암발생의 유전자-환경 상호작용 규명을 위한 모델을 개발하고, 개인화된 맞춤예방의학(personalized preventive medicine)의 근거지식을 제공할 수 있으며 질병예방 정책 개발 및 적용을 위한 근거를 생산함으로써 우리나라 암관리 정책 사업 평가 및 중장기 연구사업 기획을 위한 자료로 활용될 수 있다.

Citations

Citations to this article as recorded by

Association between dietary habits and incident thyroid cancer: A prospective cohort study
Linh Thi Dieu Nguyen, Madhawa Gunathilake, Jeonghee Lee, Jeongseon Kim
Frontiers in Nutrition.2023;[Epub]     CrossRef
Association of Dietary Fiber Intake With Gastrointestinal Tract Cancer Among Korean Adults
Shinyoung Jun, Jeonghee Lee, Jeongseon Kim
JAMA Network Open.2023; 6(3): e234680.     CrossRef
A comparison of machine learning models and Cox proportional hazards models regarding their ability to predict the risk of gastrointestinal cancer based on metabolic syndrome and its components
Tao Thi Tran, Jeonghee Lee, Madhawa Gunathilake, Junetae Kim, Sun-Young Kim, Hyunsoon Cho, Jeongseon Kim
Frontiers in Oncology.2023;[Epub]     CrossRef
Riboflavin intake, MTRR genetic polymorphism (rs1532268) and gastric cancer risk in a Korean population: a case–control study
Y-Thanh Lu, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
British Journal of Nutrition.2022; 127(7): 1026.     CrossRef
Association between metabolic syndrome and its components and incident colorectal cancer in a prospective cohort study
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Jeongseon Kim
Cancer.2022; 128(6): 1230.     CrossRef
Association Between Dietary Patterns and Dyslipidemia in Korean Women
Jeonghee Lee, Tung Hoang, Seohyun Lee, Jeongseon Kim
Frontiers in Nutrition.2022;[Epub]     CrossRef
Influence of Fasting Glucose Level on Gastric Cancer Incidence in a Prospective Cohort Study
Tao Thi Tran, Jeonghee Lee, Madhawa Gunathilake, Hyunsoon Cho, Jeongseon Kim
Cancer Epidemiology, Biomarkers & Prevention.2022; 31(1): 254.     CrossRef
Association between body mass index and oesophageal cancer mortality: a pooled analysis of prospective cohort studies with >800 000 individuals in the Asia Cohort Consortium
Sangjun Lee, Jieun Jang, Sarah Krull Abe, Shafiur Rahman, Eiko Saito, Rashedul Islam, Prakash C Gupta, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Woon-Puay Koh, Atsuko Sadakane, Ichiro Tsuji, Jeongseon Kim, Isao Oze, Chisato Nagata, San-Lin You, Myung-He
International Journal of Epidemiology.2022; 51(4): 1190.     CrossRef
Diets high in glycemic index and glycemic load are associated with an increased risk of metabolic syndrome among Korean women
Shinyoung Jun, Seohyun Lee, Jeonghee Lee, Jeongseon Kim
Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(5): 1154.     CrossRef
Seaweed and Iodine Intakes and SLC5A5 rs77277498 in Relation to Thyroid Cancer
Tung Hoang, Eun Kyung Lee, Jeonghee Lee, Yul Hwangbo, Jeongseon Kim
Endocrinology and Metabolism.2022; 37(3): 513.     CrossRef
Association between dietary intake networks identified through a Gaussian graphical model and the risk of cancer: a prospective cohort study
Madhawa Gunathilake, Tung Hoang, Jeonghee Lee, Jeongseon Kim
European Journal of Nutrition.2022; 61(8): 3943.     CrossRef
Nutrition-wide association study of microbiome diversity and composition in colorectal cancer patients
Tung Hoang, Min Jung Kim, Ji Won Park, Seung-Yong Jeong, Jeeyoo Lee, Aesun Shin
BMC Cancer.2022;[Epub]     CrossRef
The Korea Cohort Consortium: The Future of Pooling Cohort Studies
Sangjun Lee, Kwang-Pil Ko, Jung Eun Lee, Inah Kim, Sun Ha Jee, Aesun Shin, Sun-Seog Kweon, Min-Ho Shin, Sangmin Park, Seungho Ryu, Sun Young Yang, Seung Ho Choi, Jeongseon Kim, Sang-Wook Yi, Daehee Kang, Keun-Young Yoo, Sue K. Park
Journal of Preventive Medicine and Public Health.2022; 55(5): 464.     CrossRef
Relationship Between Physical Activity Levels and Thyroid Cancer Risk: A Prospective Cohort Study in Korea
Anh Quynh Bui, Madhawa Gunathilake, Jeonghee Lee, Eun Kyung Lee, Jeongseon Kim
Thyroid.2022; 32(11): 1402.     CrossRef
Associations of coffee and tea consumption with lung cancer risk
Jingjing Zhu, Stephanie A. Smith‐Warner, Danxia Yu, Xuehong Zhang, William J. Blot, Yong‐Bing Xiang, Rashmi Sinha, Yikyung Park, Shoichiro Tsugane, Emily White, Woon‐Puay Koh, Sue K. Park, Norie Sawada, Seiki Kanemura, Yumi Sugawara, Ichiro Tsuji, Kim Rob
International Journal of Cancer.2021; 148(10): 2457.     CrossRef
Differences in Dietary Patterns Identified by the Gaussian Graphical Model in Korean Adults With and Without a Self-Reported Cancer Diagnosis
Tung Hoang, Jeonghee Lee, Jeongseon Kim
Journal of the Academy of Nutrition and Dietetics.2021; 121(8): 1484.     CrossRef
Network Analysis of Demographics, Dietary Intake, and Comorbidity Interactions
Tung Hoang, Jeonghee Lee, Jeongseon Kim
Nutrients.2021; 13(10): 3563.     CrossRef
The classification capability of the Asia Pacific Colorectal Screening score in Korea: an analysis of the Cancer Screenee Cohort
Xuan Quy Luu, Kyeongmin Lee, Jeongseon Kim, Dae Kyung Sohn, Aesun Shin, Kui Son Choi
Epidemiology and Health.2021; 43: e2021069.     CrossRef
The U‐shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case–control study from eight East Asian cohort studies
Jieun Jang, Tianyi Wang, Hui Cai, Fei Ye, Gwen Murphy, Taichi Shimazu, Philip R Taylor, You‐Lin Qiao, Keun‐Young Yoo, Sun Ha Jee, Jeongseon Kim, Sheau‐Chiann Chen, Christian C Abnet, Shoichiro Tsugane, Wei Zheng, Xiao‐Ou Shu, Michael Pawlita, Sue K. Park,
International Journal of Cancer.2020; 147(3): 777.     CrossRef
Comorbidity Risk Score in Association with Cancer Incidence: Results from a Cancer Screenee Cohort
Tung Hoang, Jeonghee Lee, Jeongseon Kim
Cancers.2020; 12(7): 1834.     CrossRef
Quality of Bowel Preparation for Colonoscopy in Patients with a History of Abdomino-Pelvic Surgery: Retrospective Cohort Study
Bun Kim, Byung Chang Kim, Jeongseon Kim, Hyun Jin Oh, Kum Hei Ryu, Bum Joon Park, Dae Kyung Sohn, Chang Won Hong, Kyung Su Han
Yonsei Medical Journal.2019; 60(1): 73.     CrossRef
Lifestyle Risk Factors and All-Cause and Cardiovascular Disease Mortality: Data from the Korean Longitudinal Study of Aging
Inhwan Lee, Shinuk Kim, Hyunsik Kang
International Journal of Environmental Research and Public Health.2019; 16(17): 3040.     CrossRef
Dietary Inflammatory Index and Risk of Breast Cancer Based on Hormone Receptor Status: A Case-Control Study in Korea
Lee, Quiambao, Lee, Ro, Lee, Jung, Sung, Kim
Nutrients.2019; 11(8): 1949.     CrossRef
Interaction between alcohol consumption and methylenetetrahydrofolate reductase polymorphisms in thyroid cancer risk: National Cancer Center cohort in Korea
Sarah Yang, Jeonghee Lee, Yoon Park, Eun Kyung Lee, Yul Hwangbo, Junsun Ryu, Joohon Sung, Jeongseon Kim
Scientific Reports.2018;[Epub]     CrossRef
Genetic variations in TAS2R3 and TAS2R4 bitterness receptors modify papillary carcinoma risk and thyroid function in Korean females
Jeong-Hwa Choi, Jeonghee Lee, Sarah Yang, Eun Kyung Lee, Yul Hwangbo, Jeongseon Kim
Scientific Reports.2018;[Epub]     CrossRef
Helicobacter pyloriblood biomarker for gastric cancer risk in East Asia
Hui Cai, Fei Ye, Angelika Michel, Gwen Murphy, Shizuka Sasazuki, Philip R Taylor, You-Lin Qiao, Sue K Park, Keun-Young Yoo, Sun Ha Jee, Eo Rin Cho, Jeongseon Kim, Sheau-Chiann Chen, Christian C Abnet, Shoichiro Tsugane, Qiuyin Cai, Xiao-Ou Shu, Wei Zheng,
International Journal of Epidemiology.2016; 45(3): 774.     CrossRef
Association between nutrient intake and thyroid cancer risk in Korean women
Young Ae Cho, Jeonghee Lee, Jeongseon Kim
Nutrition Research and Practice.2016; 10(3): 336.     CrossRef

Cohort Profile

The Korean social life, health and aging project-health examination cohort

Ju-Mi Lee, Won Joon Lee, Hyeon Chang Kim, Wungrak Choi, Jina Lee, Kiho Sung, Sang Hui Chu, Yeong-Ran Park, Yoosik Youm

Epidemiol Health. 2014;36:e2014003.   Published online May 13, 2014

DOI: https://doi.org/10.4178/epih/e2014003

21,047 View

186 Download

20 Citations

Abstract Summary PDF

Abstract
The Korean Social Life, Health, and Aging Project (KSHAP) is a population-based longitudinal study of health determinants among elderly Koreans. The target population of the KSHAP are people aged 60 years or older and their spouses living in a rural community of Korea. A complete enumeration survey was conducted in the first wave of the KSHAP on 94.7% (814 of 860) of the target population between December 2011 and July 2012. The KSHAP-Health Examination (KSHAP-HE) cohort consists of 698 people who completed additional health examinations at a public health center (n=533) or at their home (n=165). Face-to-face questionnaires were used to interview participants on their demographics, social network characteristics, medical history, health behaviors, cognitive function, and depression symptoms. Health center examinations included anthropometric measures, body impedance analysis, resting blood pressure measurement, radial artery tonometry, bone densitometry, the timed up-and-go test, and fasting blood analysis. However, only anthropometric measures, blood pressure measurement, and non-fasting blood analysis were available for home health examinations. Collaboration is encouraged and access to the KSHAP baseline data will be available via the website of the Korean Social Science Data Archive (http://www.kossda.or.kr).

Summary

Korean summary
한국인의 사회적 삶, 건강과 노화에 대한 조사(Korean Social Life, Health, and Aging Project, KSHAP) 연구는 노인 건강의 사회적 결정요인과 그 상호작용을 평가하는 것을 목적으로 한다. 이를 위하여 사회연결망분석(social network analysis) 기법을 도입하였다. 사회연결망분석은 개인간의 관계를 네트워크로 파악하는 개념으로, 본 연구에서는 지역사회 전체의 사회연결망 안에서 개인의 특성 및 개인간 상호작용의 특성이 신체적 정신적 건강에 미치는 영향을 연구하고자 한다. 대상인구집단은 인천광역시 강화군 일개 면 지역의 60세 이상 인구 및 그 배우자이며, 전체 860명의 모집단에서 814명(94.7%)의 건강면접조사 및 사회연결망 분석을 완료하였으며, 이 가운데 보건지소(533명) 또는 가정(165명)에서 추가 건강검진을 수행한 698명을 대상으로 KSHAP-Health Examination (KSHAP-HE) 코호트를 구축하였다.

Citations

Citations to this article as recorded by

The Effect of Cognitive Impairment on the Association Between Social Network Properties and Mortality Among Older Korean Adults
Eunji Kim, Kiho Sung, Chang Oh Kim, Yoosik Youm, Hyeon Chang Kim
Journal of Preventive Medicine and Public Health.2023; 56(1): 31.     CrossRef
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Seyul Kwak, Hairin Kim, Jeanyung Chey
Aging, Neuropsychology, and Cognition.2022; : 1.     CrossRef
Neural and social correlates of attitudinal brokerage: using the complete social networks of two entire villages
Yoosik Youm, Junsol Kim, Seyul Kwak, Jeanyung Chey
Proceedings of the Royal Society B: Biological Sciences.2021; 288(1944): 20202866.     CrossRef
More Teeth and Posterior Balanced Occlusion Are a Key Determinant for Cognitive Function in the Elderly
Taejun Park, Yun-Sook Jung, Keunbada Son, Yong-Chul Bae, Keun-Bae Song, Atsuo Amano, Youn-Hee Choi
International Journal of Environmental Research and Public Health.2021; 18(4): 1996.     CrossRef
Social connectedness and hair cortisol in community-dwelling older adults
Sung-Ha Lee, Ekaterina Baldina, Eun Lee, Yoosik Youm
Comprehensive Psychoneuroendocrinology.2021; 6: 100053.     CrossRef
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Seyul Kwak, Hairin Kim, Hoyoung Kim, Yoosik Youm, Jeanyung Chey
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Taejun Park, Hyojin Heo, Min-Jeong Cho, Hyeon Chang Kim, Yoosik Youm, Keun-Bae Song, Youn-Hee Choi
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